GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10935120 | 1 | rs13087875 | chr3:134261123 | CEP63 | chr3:134204575-134293852:+ | -0.14 | -3.72 | 0.000208 | Height |
| BRCA | cis | rs13088281 | 1 | rs13088281 | chr3:53147576 | TMEM110 | chr3:52867139-52931547:- | -0.27 | -4.62 | 4.29E-6 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs7647973 | 1 | rs13088309 | chr3:49368317 | AMT | chr3:49454212-49460012:- | 0.14 | 4.75 | 2.3E-6 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs13088309 | chr3:49368317 | CCDC36 | chr3:49235861-49295537:+ | 0.1 | 3.87 | 0.000117 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs13088309 | chr3:49368317 | NCKIPSD | chr3:48711280-48723334:- | 0.16 | 3.96 | 8.06E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs13088309 | chr3:49368317 | P4HTM | chr3:49027341-49044579:+ | 0.11 | 4.54 | 6.25E-6 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs13088309 | chr3:49368317 | TREX1 | chr3:48501186-48509043:+ | -0.11 | -3.62 | 0.000312 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs13088309 | chr3:49368317 | WDR6 | chr3:49044637-49053386:+ | -0.14 | -4.04 | 5.79E-5 | Menarche (age at onset) |
| BRCA | cis | rs9847710 | 1 | rs13088455 | chr3:53087482 | ITIH4 | chr3:52847007-52866554:- | 0.11 | 3.85 | 0.000125 | Ulcerative colitis |
| BRCA | cis | rs2070488 | 1 | rs13089394 | chr3:38446309 | LOC100128640 | chr3:38492524-38496311:- | 0.13 | 3.56 | 0.000382 | Electrocardiographic conduction measures |
| BRCA | cis | rs2070488 | 1 | rs13089394 | chr3:38446309 | XYLB | chr3:38388251-38456467:+ | 0.21 | 6.02 | 2.41E-9 | Electrocardiographic conduction measures |
| BRCA | cis | rs10935120 | 1 | rs13089966 | chr3:134279197 | ANAPC13 | chr3:134196547-134204865:- | -0.41 | -13.19 | 6.77E-37 | Height |
| BRCA | cis | rs10935120 | 1 | rs13089966 | chr3:134279197 | CEP63 | chr3:134204575-134293852:+ | -0.14 | -3.72 | 0.000212 | Height |
| BRCA | cis | rs10935120 | 1 | rs13090969 | chr3:134307257 | ANAPC13 | chr3:134196547-134204865:- | -0.4 | -12.86 | 2.65E-35 | Height |
| BRCA | cis | rs10935120 | 1 | rs13090969 | chr3:134307257 | CEP63 | chr3:134204575-134293852:+ | -0.13 | -3.58 | 0.000362 | Height |